Bioelectronics, Paul R. Berger
Advisor: Paul R. Berger
Mr. Le (Masters)
Thomas Rosol (Professor, OSU Veterinary Biosciences)
Ed McGlumphy Jr. (Professor, Restorative/Prosthetic, OSU College of Dentistry)
Ali Rezai (Professor, Neurological Surgery, OSU College of Medicine)
Phillip Popovich (Professor, Neurological Surgery, OSU College of Medicine)
Former Graduate Students:
Ms. Anisha Ramesh (ECE Ph.D. 2012)
Ms. Fang "Freda" Ren (ECE Master's thesis 2012)
Ned Ivanov (ECE/Pre-Med undergrad researcher, BSE 2013)
Tai Cheng (ECE/Pre-Med undergrad researcher)
Image courtesy of: http://www.ainbio.com/
Importance of the Problem:
This project examines the usage of bio-sutstainable and bio-compatible electronics for
in vivo usage. We work on FET-based sensors and FET-based accuators, including protein sensors,
and in particular immunoFETs and bioFETs.
Brief Description of Our Work and Results:
Essentially, when a generic in vivo silicon
based sensor is used, it will drift with its
threshold voltage constantly moving as
alkali ions (i.e. Na and K) intercalate into
the standard silicon dioxide gate oxide.
Here we report on a drift-free bio-capacitor
that can be the platform for drift-free biosensors
The substitution of silicon dioxide with aluminium
oxide deposited by atomic layer deposition (ALD)
already shows extreme promise in blocking ion
penetration. Our exploration of other alternatives
is just commencing.
For once application, we aim to facilitate the
detection of organ transplant rejection
before it is too late, allowing proper dosing
of patients with anti-rejection medicines. In addition,
we are laying a foundation for developing
implantable artificial neurons. Alkthough it is true that
there are a few common implanted electronics, such as pace
makers, but these are always encapsulated inside stainless
steel treated housings and the electronics are never in
direct contact with bodily fluids. Advances, such as this here,
could open the door to electronics interacting
directly with the human body, both
sensing and stimulating.
Awards, Citations and Recognitions
- "ImmunoFET devices to interrogate protein content of tissues
and biological fluids,". Stephen C. Lee, Wu Lu, Leonard Brillson, Gregg Hadley,
Ron Pelletier and Paul R. Berger [Disclosure submitted August 11, 2011,
Provisional patent filed January 23, 2013].
- "Ionic Barrier for Floating Gate in vivo Biosensors,". Paul R. Berger
and Anisha Ramesh [Disclosure submitted August 3, 2010; Provisional patent
filed September 22, 2011, Full patent filed September 21, 2012].
- "Fibre optic probe with Electroluminescent Light at Distal End," Alec Gunner,
Karl Stephen Heeks, Peter Devine, Julian Charles Carter, George Bead,
Richard O.Dell, Ian Millard and Paul Berger, filed by Cambridge Display Technology Limited
in Great Britain.
- Great Britain awarded (Filed November 22, 1999, App. No. GB9927594.3, Granted May 23, 2001, GB2356464).
- "Covering," filed by Cambridge Display Technology Limited in Great Britain (App. No. GB9928694.0), Filed December 3, 1999.
Ionic Barrier for Permeable Bio-Electronics like Silicon CMOS
- "Towards in vivo Biosensors for Low-Cost Protein Sensing,".
Anisha Ramesh, Fang Ren, Paul R. Berger, Patricia Casal, Andy Theiss,
Samit Gupta, and Stephen Craig Lee, Electronics Letters, vol. 49,
pp. 450-451 (March 28, 2013). Plus, Berger Interview by Editor on page 436.
240 kB (PDF)
- "Interfacial Design and Structure of Protein/Polymer Films on Oxidized AlGaN Surfaces,".
Samit K. Gupta, Hao-Hsuan Wu, Kwang J. Kwak, Patricia Casal, Theodore R. Nicholson III,
Xuejin Wen, R. Anisha, Bharat Bhushan, Paul R. Berger, Wu Lu, Leonard J. Brillson,
Stephen Craig Lee, Journal of Physics D: Applied Physics, vol. 44,
034010, pp. 1-12 (January 26, 2011).
- "Rational Enhancement of Nanobiotechnological Device Functions Illustrated by Partial
Optimization of a Protein-Sensing Field Effect Transistor,". Theodore R. Nicholson III,
Samit Gupta, Xuejin Wen, Hao-Hsuan Wu, R. Anisha, Patricia Casal, Kwang J. Kwak,
Bharat Bhushan, Paul R. Berger, Wu Lu, Leonard J. Brillson, Stephen C. Lee.
Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanoengineering
and Nanosystems (Proceedings/Special Issue Paper for conference in Edinborough, Scotland
June 9, 2010), vol. 223, JNN184, pp. 149-161 (2010).
- "Al2O3 Gate Dielectric with Ion Impermeability for
in-vivo Biocircuitry,. Anisha Ramesh, Fang Ren,
Patricia Casal, Andy Theiss, Samit Gupta, Stephen Craig Lee
and Paul R. Berger, 2011 Fall MRS Meeting.
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Last updated April 27, 2013.
Paul R. Berger's Research page
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